Selective serotonin reuptake inhibitor-induced cell death: in search of a mechanism
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چکیده
منابع مشابه
Selective serotonin reuptake inhibitor-induced cell death: in search of a mechanism
Background Selective serotonin reuptake inhibitors (SSRIs) have been observed to drive programmed cell death in Burkitt lymphoma cells. Accordingly, they were proposed as a new modality in the treatment of Burkitt lymphoma. However, they induce apoptosis with little if any appreciable selectivity. Actually, the selectivity appears to be so low that SSRIs can also kill protozoa (such as Trichomo...
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Background and Purpose The aim of the study was to investigate the efficacy and safety of the selective serotonin reuptake inhibitor citalopram in treating poststroke depression, since available treatments are usually poorly tolerated. Methods A 6-week double-blind, placebo-controlled trial was undertaken. Diagnosis and outcome were determined using the Hamilton Depression Scale, and unwanted e...
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OBJECTIVES Selective serotonin reuptake inhibitor (SSRI)-induced apathy is characterized by a lack of motivation that is not a result of sedation or symptoms of depression. This report describes two pediatric cases of SSRI-induced apathy, one of which is the first reported case in a child with a non-OCD (obsessive compulsive disorder) anxiety disorder. METHODS The sample included 43 participa...
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Serotonin syndrome is a rare but potentially fatal adverse drug reaction associated with increased serotonergic activity in the central nervous system. It is characterized by a triad of symptoms, which include altered mental status, neuromuscular hyperactivity, and autonomic instability or hyperactivity. Due to the potential of rapid onset, it is important for clinicians to recognize the signs ...
متن کاملcomparing the efficacy of bupropion and amantadine on sexual dysfunction induced by a selective serotonin reuptake inhibitor
conclusions these results provide empirical support for conducting a further study on comparing different add-on strategies for treating drug-induced sd. background antidepressant-induced sexual dysfunction (sd) is a common problem, associated with a significant risk of non-adherence. selective serotonin reuptake inhibitors (ssris) are associated with a substantial risk of sd. only 10 % of pati...
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ژورنال
عنوان ژورنال: BMC Pharmacology
سال: 2010
ISSN: 1471-2210
DOI: 10.1186/1471-2210-10-s1-a28